Expression of neuropeptide hormone receptors in human adrenal tumors and cell lines: antiproliferative effects of peptide analogues.

@article{Ziegler2009ExpressionON,
  title={Expression of neuropeptide hormone receptors in human adrenal tumors and cell lines: antiproliferative effects of peptide analogues.},
  author={Christian G. Ziegler and James D. Brown and Andrew V Schally and Axel Erler and Linda Gebauer and Andrea Treszl and Lynn Young and Lawrence M Fishman and Jorg B Engel and Holger Sven Willenberg and Stephan Petersenn and Graeme Eisenhofer and Monika Ehrhart-Bornstein and Stefan R. Bornstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 37},
  pages={
          15879-84
        }
}
Peptide analogues targeting various neuropeptide receptors have been used effectively in cancer therapy. A hallmark of adrenocortical tumor formation is the aberrant expression of peptide receptors relating to uncontrolled cell proliferation and hormone overproduction. Our microarray results have also demonstrated a differential expression of neuropeptide hormone receptors in tumor subtypes of human pheochromocytoma. In light of these findings, we performed a comprehensive analysis of relevant… CONTINUE READING

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