Expression of neuronal nitric oxide synthase (nNOS) and nitric-oxide-induced changes in cGMP in the urothelial layer of the guinea pig bladder

@article{Gillespie2005ExpressionON,
  title={Expression of neuronal nitric oxide synthase (nNOS) and nitric-oxide-induced changes in cGMP in the urothelial layer of the guinea pig bladder},
  author={James I. Gillespie and Marjanne Markerink-van Ittersum and Jan de Vente},
  journal={Cell and Tissue Research},
  year={2005},
  volume={321},
  pages={341-351}
}
The urothelium plays a sensory role responding to deformation of the bladder wall; this involves the release of adenosine trisphosphate (ATP) and nitric oxide (NO), which affect afferent nerve discharge and bladder sensation. The urothelial cells responsible for producing ATP and NO and the cellular targets, other than afferent nerves, for ATP and NO remain… CONTINUE READING