Expression of natural antimicrobials by human placenta and fetal membranes.

  title={Expression of natural antimicrobials by human placenta and fetal membranes.},
  author={Andrew King and Aarti Paltoo and Rodney W. Kelly and J-M Sallenave and Alan D. Bocking and John R. G. Challis},
  volume={28 2-3},
Preterm birth associated with infection is a major clinical problem. We hypothesized that this condition is associated with altered expression of natural antimicrobial molecules (beta-defensins (HBD), elafin). Therefore, we examined expression of these molecules and their regulation by proinflammatory cytokines in placentae and fetal membranes from term pregnancy. HBD1-3 and elafin were localized by immunohistochemistry in fetal membranes and placenta. Real-time quantitative PCR was used to… CONTINUE READING
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