Expression of myostatin in early postnatal mouse masseter and rectus femoris muscles.

  title={Expression of myostatin in early postnatal mouse masseter and rectus femoris muscles.},
  author={H. Takada and Y. Miwa and I. Sato},
  journal={Histology and histopathology},
  volume={30 11},
AIMS Myostatin (Mstn) is a member of the transforming growth factor-β (TGF-β) family that inhibits muscle differentiation. In this study, we aimed to identify the relationships between Mstn, thyroid hormone receptor alpha (TRα), and myosin heavy chain (MyHC) isoform expression during early postnatal development. METHODS We investigated the expression of Mstn, TRα, and MyHCs (embryonic, slow, IIa, IIb, and IIx) using quantitative real-time RT-PCR and ELISA (Mstn) in postnatal mouse muscles… Expand
Comparison of the expression of neurotransmitter and muscular genesis markers in the postnatal male mouse masseter and trigeminal ganglion during development
The expression of CGRP and TRPV1 in the TG and MM and the patterns of expression of different MyHC isoforms were affected by changes in feeding during male mouse development. Expand
Muscle fiber-type conversion in the transgenic pigs with overexpression of PGC1α gene in muscle.
The overexpression of PGC1α gene can promote the glycolytic muscle fiber transform to the oxidative muscle fiber in pigs, and the main differentially expressed genes were MSTN, Myog and FOXO1. Expand


Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading.
Results indicate that MSTN expression is not stronglyassociated with muscle atrophy induced by HU; however, it is strongly associated with MHC isoform IIb expression in normal muscle. Expand
Myostatin regulates fiber-type composition of skeletal muscle by regulating MEF2 and MyoD gene expression.
It is proposed that Mstn could regulate fiber-type composition by regulating the expression of MEF2C and MyoD during myogenesis, and positively regulates MEf2C levels, and negatively regulates MyOD expression in muscle. Expand
Myostatin preferentially down-regulates the expression of fast 2x myosin heavy chain in cattle.
Findings suggest that the endogenous myostatin preferentially down-regulates the expression of the fast 2x MyHC and participates in differentiation of myofiber types during early bovine myogenesis. Expand
Delayed Embryonic Development of Mouse Masseter Muscle Correlates with Delayed MyoD Family Expression
It is suggested that the delayed expression of the myoD family genes in the masseter correlates with delayed differentiation and maturation, probably due to the later functional requirements of themasseter than of the tongue. Expand
Modulation of myostatin expression during modified muscle use
  • M. Wehling, B. Cai, J. Tidball
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2000
The results show that periods of 30 min of daily muscle loading during the unloading period were sufficient to prevent significant losses of muscle mass caused by unloading, although myostatin mRNA still showed a 55% increase in concentration. Expand
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
Results suggest that GDF-8 functions specifically as a negative regulator of skeletal muscle growth, which is significantly larger than wild-type animals and show a large and widespread increase in skeletal muscle mass. Expand
Regulation of myostatin activity and muscle growth
  • S. Lee, A. Mcpherron
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
The findings suggest that the propeptide, follistatin, or other molecules that block signaling through this pathway may be useful agents for enhancing muscle growth for both human therapeutic and agricultural applications. Expand
Hypothyroidism is associated with increased myostatin expression in rats
It is demonstrated that myostatin expression is increased in hypothyroid rats, thus supporting a possible role for this factor in the pathogenesis of the muscle loss that may occur in Hypothyroidism. Expand
Transition of myosin isozymes during development of human masseter muscle. Persistence of developmental isoforms during postnatal stage.
It is shown here that the embryonic and the fetal MHC and the MLC1emb are expressed throughout perinatal and postnatal masseter development and this suggests that control of masseter muscle development involves mechanisms distinct from other body muscles, possibly as a result of either its craniofacial innervation or of a possibly different embryonic origin. Expand
Myostatin promotes the terminal differentiation of embryonic muscle progenitors.
It is shown that while myostatin overexpression in chick leads to an exhaustion of the muscle progenitor population that ultimately results in muscle hypotrophy, hisostatin loss of function in chick and mouse provokes an expansion of this population. Expand