Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.

@article{Spitz1998ExpressionOM,
  title={Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.},
  author={François Spitz and Josiane Demignon and Arlette Porteu and Axel Kahn and Jean Paul Concordet and Dominique Daegelen and Pascal Maire},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 24},
  pages={14220-5}
}
Myogenin, one of the MyoD family of proteins, is expressed early during somitogenesis and is required for myoblast fusion in vivo. Previous studies in transgenic mice have shown that a 184-bp myogenin promoter fragment is sufficient to correctly drive expression of a beta-galactosidase transgene during embryogenesis. We show here that mutation of one of the DNA motifs present in this region, the MEF3 motif, abolished correct expression of this beta-galactosidase transgene. We have found that… CONTINUE READING
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