Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinoma.

@article{Kamiya2002ExpressionOM,
  title={Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinoma.},
  author={Yuji Kamiya and Monika Puzianowska-Kuźnicka and P Mcphie and J. S. Nauman and Sheue-yann Cheng and Alicja Nauman},
  journal={Carcinogenesis},
  year={2002},
  volume={23 1},
  pages={25-33}
}
Thyroid hormone (T(3)) regulates proliferation and differentiation of cells, via its nuclear receptors (TRs). These processes have been shown to be abnormally regulated during carcinogenesis. We have previously found aberrant expression of TRalpha and TRbeta mRNAs in renal clear cell carcinoma (RCCC), suggesting possible involvement of TRs in the carcinogenesis of RCCC. To understand the molecular actions of TRs in RCCC, cDNAs for TRbeta1 and TRalpha1 were cloned from 22 RCCC tissues and 20… CONTINUE READING