Expression of multiple plasma membrane Ca(2+)-ATPases in rat pancreatic islet cells.

@article{Kamagat2000ExpressionOM,
  title={Expression of multiple plasma membrane Ca(2+)-ATPases in rat pancreatic islet cells.},
  author={Adama Kamagat{\'e} and Andr{\'e} Herchuelz and Alex Bollen and Françoise Van Eylen},
  journal={Cell calcium},
  year={2000},
  volume={27 4},
  pages={
          231-46
        }
}
When stimulated by glucose, the pancreatic beta-cell displays large oscillations of intracellular free Ca2+ concentration ([Ca2+]i). To control [Ca2+]i, the beta-cell must be equipped with potent mechanisms for Ca2+ extrusion. We studied the expression of the plasma membrane Ca(2+)-ATPases (PMCA) in three insulin secreting preparations (a pure beta-cell preparation, RINm5F cells and pancreatic islet cells), using reverse-transcribed PCR, RNase protection assay and Western blotting. The four… CONTINUE READING

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