Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.

@article{Bowen2006ExpressionOM,
  title={Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.},
  author={Laura C Bowen and Annalise V Bicknell and Mohammad Tabish and Roger A. Clegg and Huw H. Rees and Michael J Fisher},
  journal={Cellular signalling},
  year={2006},
  volume={18 12},
  pages={2230-7}
}
The cAMP-dependent protein kinase (protein kinase A, PK-A) plays a central role in the regulation of many aspects of eukaryotic cellular activity. In the free-living nematode, Caenorhabditis elegans, two genes encode PK-A-like catalytic subunits. The kin-1 gene has the potential to generate, through alternative splicing events, a multiplicity of catalytic subunit isoforms; in contrast, the F47F2.1b gene appears to encode just a single authentic catalytic subunit-like protein. Here, we report on… CONTINUE READING