Expression of multiple growth factors in a human lung cancer cell line.

@article{Betsholtz1987ExpressionOM,
  title={Expression of multiple growth factors in a human lung cancer cell line.},
  author={Christer Betsholtz and Jonas Bergh and Margaret A. Bywater and Monica Vea Pettersson and Ann Johnsson and Carl-Henrik Heldin and Rolf Ohlsson and Timothy J. Knott and Jacob Scott and Graeme I. Bell},
  journal={International journal of cancer},
  year={1987},
  volume={39 4},
  pages={
          502-7
        }
}
U-1810, a human large-cell lung cancer line, was found to express a PDGF-like growth factor. 35S-cysteine labelling and immunoprecipitation revealed the synthesis and secretion of a 31-kDa PDGF-like protein. Serum-free conditioned medium contained PDGF-receptor-competing and mitogenic activity when tested on human fibroblasts. Whereas the receptor-competing activity was fully neutralized by anti-PDGF antibodies, the mitogenic activity was only partially affected. We therefore probed U-1810 mRNA… CONTINUE READING
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