Expression of mouse mammary tumor virus superantigen mRNA in the thymus correlates with kinetics of self-reactive T-cell loss.

@article{Barnett1999ExpressionOM,
  title={Expression of mouse mammary tumor virus superantigen mRNA in the thymus correlates with kinetics of self-reactive T-cell loss.},
  author={Anna Barnett and Farah Mustafa and T J Wrona and Mary M. Lozano and Jaquelin P. Dudley},
  journal={Journal of virology},
  year={1999},
  volume={73 8},
  pages={6634-45}
}
Mouse mammary tumor virus (MMTV) encodes a superantigen (Sag) that is expressed at the surface of antigen-presenting cells in conjunction with major histocompatibility complex (MHC) type II molecules. The Sag-MHC complex is recognized by entire subsets of T cells, leading to cytokine release and amplification of infected B and T cells that carry milk-borne MMTV to the mammary gland. Expression of Sag proteins from endogenous MMTV proviruses carried in the mouse germ line usually results in the… CONTINUE READING
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