Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat

@article{Kim1995ExpressionOM,
  title={Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat},
  author={Jong S. Kim and Subhash C. Gautam and Michael Chopp and Cecylia Zaloga and Michael L. Jones and Peter A. Ward and Kenneth M. A. Welch},
  journal={Journal of Neuroimmunology},
  year={1995},
  volume={56},
  pages={127-134}
}
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287 Citations
Highly Influential Citations
9
Background Citations
91
Methods Citations
3
Results Citations
7

287 Citations

Induction of macrophage inflammatory protein MIP-1α mRNA on glial cells after focal cerebral ischemia in the rat
Differential and time-dependent expression of monocyte chemoattractant protein-1 mRNA by astrocytes and macrophages in rat brain: effects of ischemia and peripheral lipopolysaccharide administration
Overexpression of Monocyte Chemoattractant Protein 1 in the Brain Exacerbates Ischemic Brain Injury and is Associated with Recruitment of Inflammatory Cells
  • Yong Chen, J. Hallenbeck, S. Vogel
  • Biology, Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2003
TLDR
Brain infarction volumes after ischemia were significantly larger in MBP-JE mice than in wild-type controls and were accompanied by increased local transmigration and perivascular accumulation of macrophages and neutrophils, indicating that MCP-1 can contribute to inflammatory injury in stroke.
Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures
Monocyte chemoattractant protein-1 is a mediator of acute excitotoxic injury in neonatal rat brain
Hypoxic-Ischemic Injury Induces Monocyte Chemoattractant Protein-1 Expression in Neonatal Rat Brain
TLDR
The results suggest that in the developing brain, MCP-1 could represent a functionally important molecular signal for the microglial response to hypoxic-ischemic injury.
Chemokine and Inflammatory Cell Response to Hypoxia-Ischemia in Immature Rats
TLDR
The expression of mRNA for α- and β-chemokines preceded the appearance of immune cells suggesting that these molecules may have a role in the inflammatory response to insults in the immature central nervous system.
Differential production of MCP‐1 and cytokine‐induced neutrophil chemoattractant in the ischemic brain after transient focal ischemia in rats
TLDR
It is suggested that MCP‐1 in cerebral ischemia actually plays a significant role in the migration of macrophages into the lesion and that the differential temporal production of these chemokines contributes to the regulation of infiltrated leukocyte subtypes.
MIP-1alpha and MCP-1 Induce Migration of Human Umbilical Cord Blood Cells in Models of Stroke.
TLDR
MCP-1 and MIP-1alpha expression were significantly increased in the ischemic hemisphere of brain, and significantly promoted HUCB cell migration compared to the contralateral side, suggesting that the increased chemokines in theIschemic area can bind cell surface receptors on H UCB, and induce cell infiltration of systemically delivered HUCBs cells into the CNS in vivo.
Selective chemokine mRNA expression following brain injury
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References

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TLDR
Results indicate that MCP-1 is not only a chemoattractant but also a novel cytokine with the capacity to regulate several parameters of monocyte function.
Interleukin-1 beta mRNA expression in ischemic rat cortex.
TLDR
Brain interleukin-1 beta mRNA is elevated acutely after permanent focal ischemia and especially in hypertensive rats, suggesting that this potent proinflammatory and procoagulant cytokine might have a role in brain damage following ischemIA.
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TLDR
The results suggest that endothelial cells secrete a monocyte chemoattractant, MCP-1/JE, in response to inflammatory mediators, and thus may contribute to the accumulation of monocytes at sites of inflammation.
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The expression of JE and KC, other growth-factor-responsive genes that code for small secreted glycoproteins with cytokine-like properties, which may play a role in inflammation are reported on.
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TLDR
These cytokines have multiple inflammatory activities in the central nervous system and contribute to tissue damage during pneumococcal meningitis, as suggested by a rabbit model of meningeal inflammation.
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TLDR
Data reveal that MIP 1 peptides act as autocrine modulators of their cells of origin, and raise the possibility that Mip 1 peptide may play a role in modulating macrophage responses to inflammatory stimuli in vivo.
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TLDR
Results suggest that EC-produced MCP-1/JE may mediate some of IL-4's effects on monocyte physiology in vivo, including IL- 4's anti-tumor properties.
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