Expression of monocyte chemoattractant protein-1 (MCP-1) by rat alveolar macrophages during chronic lung injury.

@article{Brieland1993ExpressionOM,
  title={Expression of monocyte chemoattractant protein-1 (MCP-1) by rat alveolar macrophages during chronic lung injury.},
  author={Joan K. Brieland and Michael L. Jones and Craig M. Flory and Gerald R. Miller and Jeffrey S. Warren and Sem H. Phan and Joseph C. Fantone},
  journal={American journal of respiratory cell and molecular biology},
  year={1993},
  volume={9 3},
  pages={300-5}
}
Using a well-characterized model of bleomycin-induced pulmonary fibrosis in the rat, we determined that there was a time-dependent elaboration of monocyte chemotactic activity in bronchoalveolar lavage fluid. Northern hybridization analysis revealed markedly increased expression of rat monocyte chemoattractant protein-1 (MCP-1) mRNA in alveolar macrophages (AMs) from rats following induction of pulmonary fibrosis. Monocyte chemotactic activity was also significantly increased in conditioned… CONTINUE READING
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