Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of the mitogen-activated protein kinases, in rheumatoid arthritis: up-regulation by interleukin-1beta and glucocorticoids.

@article{Toh2004ExpressionOM,
  title={Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of the mitogen-activated protein kinases, in rheumatoid arthritis: up-regulation by interleukin-1beta and glucocorticoids.},
  author={Myew-Ling Toh and Yuan Yang and Michelle Leech and Lanie L Santos and Eric F Morand},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 10},
  pages={3118-28}
}
OBJECTIVE Mitogen-activated protein kinases (MAPKs) are activated by proinflammatory stimuli. MAPK phosphatases (MKPs), in particular MKP-1, have been identified as endogenous negative regulators of MAPK activation. Since MAPKs are known to be important in rheumatoid arthritis (RA) synoviocyte activation, this study assessed the expression, regulation, and function of MKP-1 in RA. METHODS MKP-1 expression was measured by Western blotting (WB) and real-time polymerase chain reaction (PCR). RA… CONTINUE READING