Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells.

@article{Miyasaka2004ExpressionOM,
  title={Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells.},
  author={Kay Miyasaka and Rikinari Hanayama and Masato Tanaka and Shigekazu Nagata},
  journal={European journal of immunology},
  year={2004},
  volume={34 5},
  pages={1414-22}
}
Milk fat globule epidermal growth factor 8 (MFG-E8) is a protein that stimulates the engulfment of apoptotic cells by phagocytes. Here, we show that mouse immature dendritic cells (DC) generated in vitro by culturing bone marrow progenitors in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF), and Langerhans cells present in the skins, expressed MFG-E8. Bone marrow-derived macrophages generated by M-CSF did not express MFG-E8. MFG-E8 expressed in immature DC was found to… CONTINUE READING
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