Expression of midkine and pleiotropin in ovarian tumors.

  title={Expression of midkine and pleiotropin in ovarian tumors.},
  author={Takeshi Nakanishi and Kenji Kadomatsu and Takako Okamoto and Yutaka Tomoda and Takashi Muramatsu},
  journal={Obstetrics and gynecology},
  volume={90 2},
OBJECTIVE To compare the expression of midkine and pleiotropin in malignant ovarian tumors with that in normal and benign ovarian tissue. METHODS Total RNA was isolated from 23 samples of normal ovaries, 15 benign ovarian tumors, and 36 malignant ovarian tumors. Midkine and pleiotropin gene expression was examined by using Northern blot analysis. To confirm the localization of midkine expression, in situ hybridization and immunohistochemical analyses were performed. The truncated midkine… CONTINUE READING
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