Expression of microtubule-associated protein 2 by reactive astrocytes.

  title={Expression of microtubule-associated protein 2 by reactive astrocytes.},
  author={Eldon E Geisert and Herbert G. Johnson and Lester I. Binder},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={87 10},
After an injury to the central nervous system, a dramatic change in the astrocytes bordering the wound occurs. The most characteristic feature of this process, termed reactive gliosis, is the upregulation of the intermediate filament protein, glial fibrillary acidic protein. In the present study, we show that reactive astrocytes express high levels of microtubule-associated protein 2 (MAP-2), a protein normally found in the somatodendritic compartment of neurons. When sections of injured brain… CONTINUE READING


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