Expression of memory to the terminal differentiation inducing activity of tiazofurin in HL-60 leukemia cells.

@article{Sokoloski1991ExpressionOM,
  title={Expression of memory to the terminal differentiation inducing activity of tiazofurin in HL-60 leukemia cells.},
  author={John A. Sokoloski and Alan C. Sartorelli},
  journal={Leukemia research},
  year={1991},
  volume={15 5},
  pages={
          395-402
        }
}
Tiazofurin, a potent inhibitor of inosine 5'-phosphate dehydrogenase, depletes guanine nucleotide pools and induces granulocytic maturation of HL-60 leukemia cells. These effects are reversed when cells exposed to this agent for 24 h are washed and placed in tiazofurin-free medium. HL-60 cells treated with tiazofurin for a 24 h period, retain a precommitment memory that lessens the time interval necessary for cells to express the mature phenotype upon re-exposure. That protein synthesis was… Expand
2 Citations
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