Expression of melatonin receptors in arteries involved in thermoregulation.

@article{Viswanathan1990ExpressionOM,
  title={Expression of melatonin receptors in arteries involved in thermoregulation.},
  author={Mohan Viswanathan and Jarmo T. Laitinen and Jhonny Saavedra},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 16},
  pages={
          6200-3
        }
}
Melatonin binding sites were localized and characterized in the vasculature of the rat by using the melatonin analogue 2-[125I]iodomelatonin (125I-melatonin) and quantitative in vitro autoradiography. The expression of these sites was restricted to the caudal artery and to the arteries that form the circle of Willis at the base of the brain. The arterial 125I-melatonin binding was stable, saturable, and reversible. Saturation studies revealed that the binding represented a single class of high… CONTINUE READING

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