Expression of matrix metalloproteinases in the muscle of patients with inflammatory myopathies.

@article{Choi2000ExpressionOM,
  title={Expression of matrix metalloproteinases in the muscle of patients with inflammatory myopathies.},
  author={Yong Chang Choi and Marinos C. Dalakas},
  journal={Neurology},
  year={2000},
  volume={54 1},
  pages={65-71}
}
OBJECTIVE To investigate the role of matrix metalloproteinases (MMPs) in the pathogenesis of inflammatory myopathies and the amyloid formation in sporadic inclusion body myositis (s-IBM). BACKGROUND MMPs comprise a family of calcium-dependent zinc endoproteinases induced by cytokines and secreted by inflammatory cells. They enhance T-cell migration or adhesion and degrade components of the extracellular matrix proteins. Some MMPs also have been implicated in the formation of beta-amyloid… CONTINUE READING

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