Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis.

@article{Rajendran2006ExpressionOM,
  title={Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis.},
  author={Rashmika Rajendran and Mohammed P K Rajeesh and Saleen Shaikh and V Shanthi and M. Radhakrishna Pillai},
  journal={Indian journal of dental research : official publication of Indian Society for Dental Research},
  year={2006},
  volume={17 4},
  pages={161-6}
}
Immunohistochemical staining of formalin fixed, paraffin embedded tissue sections of OSF for MMPs-1,2,9 and their tissue inhibitors TIMP-1and 2 was performed using monospecific antibodies coupled with gelatin zymography (MMP-2 and 9) for measuring enzymatic activity quantitatively and for distinguishing the active from the inactive variants of enzymes. The present study, contrary to earlier reports, recorded statistically significant increase in the levels of stromal expression of MMP-1, MMP-2… CONTINUE READING

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