Expression of matrix metalloproteinases, their inhibitors, and urokinase plasminogen activator in human meningiomas.

@article{Siddique2003ExpressionOM,
  title={Expression of matrix metalloproteinases, their inhibitors, and urokinase plasminogen activator in human meningiomas.},
  author={Khawar M. Siddique and Niranjan Yanamandra and Meena Gujrati and Dzung H. Dinh and Jasti S. Rao and William C. Olivero},
  journal={International journal of oncology},
  year={2003},
  volume={22 2},
  pages={
          289-94
        }
}
MMP-2, MMP-9, and uPA have been previously described as important to the invasive and metastatic potential of human tumors, including breast, lung, glioblastoma, and prostate. We examined the activity of these proteases and the levels of their inhibitors (TIMP-1 and TIMP-2) in a series of human meningioma tissue samples. Normal brain tissue did not show elevated levels of uPA, MMP-2 or MMP-9 activity. Meningiomas showed a mild, to moderate to significantly high level of uPA, MMP-2, and MMP-9… CONTINUE READING
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