Expression of matrix metalloproteinases, their tissue inhibitors, and osteopontin in the wall of thoracic and abdominal aortas with dilatative pathology.

@article{Lesauskait2006ExpressionOM,
  title={Expression of matrix metalloproteinases, their tissue inhibitors, and osteopontin in the wall of thoracic and abdominal aortas with dilatative pathology.},
  author={Vaiva Lesauskaitė and Maria Carmela Epistolato and Marta Castagnini and Sigitas Urbonavi{\vc}ius and Piero Tanganelli},
  journal={Human pathology},
  year={2006},
  volume={37 8},
  pages={1076-84}
}
Matrix metalloproteinases (MMPs) degrade extracellular matrix and may play a central role in the pathogenesis of aortic aneurysms. We studied 2 groups of patients: 15 with dilatative pathology of the ascending thoracic aorta and 17 with aneurysm of the abdominal aortic wall (AAA). We compared the expression of MMPs, tissue inhibitors of matrix metalloproteinases (TIMPs), and osteopontin in the wall of thoracic and abdominal aneurysms. In AAA, MMP-9 and TIMP-1 expression in inflammatory cells… CONTINUE READING
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