Expression of maspin in gestational trophoblastic disease.

  title={Expression of maspin in gestational trophoblastic disease.},
  author={Hang Li and See Wai Leung and Annie Nga-Yin Cheung and May Mei-Yung Yu and Loucia Kit-Ying Chan and Yick-fu Wong},
  journal={Gynecologic oncology},
  volume={101 1},
BACKGROUND Maspin is a tumor suppressor gene whose expression is altered in neoplasia and malignancies of many tissues. In the human placenta, the maspin gene is expressed in trophoblastic cells and might act as an inhibitory regulator of trophoblastic invasion. Hence, in gestational trophoblastic disease (GTD), where there is increased propensity for invasion in the trophoblastic tissue, we hypothesized that maspin expression would be decreased. The present study aimed at investigating the… CONTINUE READING
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