Expression of mammalian target of rapamycin in atherosclerotic plaques is decreased under diabetic conditions: a mechanism for rapamycin resistance.

@article{Zhang2014ExpressionOM,
  title={Expression of mammalian target of rapamycin in atherosclerotic plaques is decreased under diabetic conditions: a mechanism for rapamycin resistance.},
  author={Yan Zhang and Qiang Sheng Wang and Dachun Yang and De Zhi Li and Bing Feng Tang and Yongjian Yang and Shuangtao Ma},
  journal={Molecular medicine reports},
  year={2014},
  volume={9 6},
  pages={2388-92}
}
Our previous study demonstrated that diabetes increases in-stent restenosis following rapamycin-eluting stent placement, which was defined as rapamycin resistance. However, the underlying mechanisms of rapamycin resistance remain to be determined. In the present study, male apolipoprotein E-deficient (ApoE-/-) mice were randomly divided into control and diabetic groups. Diabetes was induced by injecting streptozocin (STZ). The hyperglycemic state, defined as a fasting plasma glucose level >13… CONTINUE READING