Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75ngfr, TrkA, TrkB, and TrkC) in the adult human peripheral nervous system and nonneural tissues

@article{Yamamoto2006ExpressionOM,
  title={Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75ngfr, TrkA, TrkB, and TrkC) in the adult human peripheral nervous system and nonneural tissues},
  author={M. Yamamoto and G. Sobue and K. Yamamoto and T. Mitsuma},
  journal={Neurochemical Research},
  year={2006},
  volume={21},
  pages={929-938}
}
The steady-state mRNA levels of the four neurotrophic factors of nerve growth factor (NGF), brain-dervied neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and glial cell line-derived neurotrophic factor (GDNF) and their receptors (p74ngfr, trkA, trkB and trkC) in the adult human peripheral nervous system (PNS) as well as nonneural tissues were examined using quantitative reverse transcription-polymerase chain reaction (RT-PCR). NGF and BDNF mRNA levels were high in the heart and spleen as well… Expand
Expression of mRNAs for Neurotrophins (NGF, BDNF, and NT-3) and their Receptors (p75NGFR, Trk, TrkB, and TrkC) in Human Peripheral Neuropathies
The steady-state mRNA levels of NGF, BDNF and NT-3, and the mRNA levels of their receptors p75NGFR, trk, trk,B and trkC were examined in various human peripheral neuropathies, to determine theExpand
Neurotrophin and neurotrophin receptor protein expression in the human lung.
TLDR
The widespread expression of NTs and their receptors in different components of the lung suggests that these factors may contribute to regulate cell function in human lung. Expand
BDNF and NT-3 regulation of trkB and trkC mRNA levels in the developing chick spinal cord
TLDR
The data indicate that neurotrophin receptor mRNA levels in the spinal cord are regulated by neurotrophic factors during embryonic development. Expand
Effects of castration on the immunoreactivity to NGF, BDNF and their receptors in the pelvic ganglia of the male rat.
TLDR
It is suggested that castration modulates the expression of neurotrophins and their receptors in pelvic autonomic neurons in normal and castrated rats. Expand
Expression of mRNAs for Ciliary Neurotrophic Factor (CNTF), Leukemia Inhibitory Factor (LIF), Interleukin-6 (IL-6), and Their Receptors (CNTFRα, LIFRβ, IL-6Rα, and gp130) in Human Peripheral Neuropathies
TLDR
The neuropoietic cytokine family and its receptor expressions in the diseased human nerves are regulated by an underlying pathology-related process rather than type of diseases, and could play a role in peripheral nerve regeneration and repair. Expand
Apoptotic Effects of Reduced Brain Derived Neurotrophic Factor (BDNF) on Mouse Liver and Kidney
TLDR
It was found that BDNF is protective against apoptosis in liver and kidney, and the lack of difference between the studied groups in terms of intensity and distribution of BDNF receptors, suggests thatBDNF receptor distribution in the liver and kidneys tissues may be different from the nervous system or that BD NF may differ in affinity for these receptors. Expand
Glial cell line-derived neurotrophic factor (GDNF) enhances sympathetic neurite growth in rat hearts at early developmental stages.
TLDR
Investigation of the effect of neurotrophic factors on sympathetic neurite growth towards cardiomyocytes revealed that GDNF is abundantly expressed in the hearts of embryos and neonates, but not in adult hearts, and plays an important role in inducing cardiac sympathetic innervation at the early developmental stages. Expand
Expression of the neurotrophin receptor TrkB in the mouse liver
TLDR
The role of TrkB in the murine liver in maintaining the innervation of the organ, and more importantly throughout an unknown mechanism in controlling the hepatic haematopoietic function, is supported. Expand
Expression and anatomical distribution of TrkB in the encephalon of the adult zebrafish (Danio rerio)
TLDR
The present results demonstrate, for the first time, that, as in mammals, the encephalon of adult zebrafish expresses TrkB in specific zones related to food intake, behaviour or motor activity. Expand
Gene Expression and Localization of NGF and Its Cognate Receptors NTRK1 and NGFR in the Sex Organs of Male Rabbits.
TLDR
The present data suggest that the NGF system is involved in the testicular development and spermatogenesis of rabbits and that NGF may act as a potential ovulation-inducing factor being abundantly present in the seminal plasma. Expand
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TLDR
The lag-time for forskolin-induces down-regulation of LNGFR mRNA was far greater than that for NGF mRNA increase and BDNF mRNA suppression, which coincided with the optimal concentration for Schwann cells to differentiate. Expand
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Insight is provided into the role of Trk-family receptors and nerve growth factor-related neurotrophins during development and suggest that, in addition to regulating neuronal survival and differentiation, the neurotrophin/Trk receptor system may have broader physiological effects. Expand
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TLDR
It is shown that brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of gp 145trkB, one of the receptors encoded by trkB, indicating that gp145trkB may function as a neurotrophic receptor for BDNF andNT-3. Expand
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TLDR
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TLDR
The expression of neurotrophin-4 mRNA was up-regulated after stimulation of immune cells with the mitogens concanavalin A or lipopolysaccharide or with the inflammatory mediator leukotriene B4, suggesting that neurotrophIn-4 could be secreted by immunocompetent cells and may be involved in inflammatory processes. Expand
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TLDR
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The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons
The pattern of retrograde axonal transport of the target-derived neurotrophic molecule, nerve growth factor (NGF), correlates with its trophic actions in adult neurons. We have determined that theExpand
Gene expression of high- (p140 trk ) and low-affinity nerve growth factor receptor (LNGFR) in the adult and aged human peripheral nervous system
TLDR
The spatial patterns of the trk and LNGFR gene expression in the adult human PNS were similar to those observed in the rat, mouse and chick, and their expression was well preserved in the aged. Expand
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