Expression of mRNA of chemokine receptor CXCR4 in feline mammary adenocarcinoma.


The expression of mRNA of the chemokine receptor CXCR4 in 65 surgically resected mammary adenocarcinomas from cats was investigated by in situ hybridisation. No expression of the receptor's mRNA was detectable in the mammary tissue of healthy cats, but it was expressed in areas adjacent to necrosis, surrounding blood vessels and cells infiltrating the lymphatics of 47 (72.3 per cent) of the 65 samples. There was a significant relationship between lymphatic infiltration by neoplastic cells and the expression of the receptor's mRNA (P < 0.005), but there was no significant relationship between its expression and the one-year survival of the cats.

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@article{Tanabe2002ExpressionOM, title={Expression of mRNA of chemokine receptor CXCR4 in feline mammary adenocarcinoma.}, author={Satoshi Tanabe and Taeko Nakadai and Hidefumi Furuoka and Toshio Oomachi and Yutaka Kobayashi and Yoshitaka Omata and Teruhide Koyama and Eiichi Hondo and Yuji Uzuka and Takao Sarashina and Rio John T Ducusin and Toshio Shida and M E Dorf}, journal={The Veterinary record}, year={2002}, volume={151 24}, pages={729-33} }