Expression of mRNA for the serotonin 5-hydroxytryptamine1D beta receptor subtype in human and bovine cerebral arteries.

@article{Hamel1993ExpressionOM,
  title={Expression of mRNA for the serotonin 5-hydroxytryptamine1D beta receptor subtype in human and bovine cerebral arteries.},
  author={Edith Hamel and Erzhong Fan and Donald G. Linville and Vivian Ting and Jean Guy Villemure and Lian Sai Chia},
  journal={Molecular pharmacology},
  year={1993},
  volume={44 2},
  pages={242-6}
}
Serotonin [5-hydroxytryptamine (5-HT)] has been implicated in the pathophysiology of migraine, and the clinical efficacy of the 5-HT1B/5-HT1D receptor agonist sumatriptan points to neural and/or vascular 5-HT1D receptors as relevant targets in migraine therapy. We characterized the human and/or bovine 5-HT1D receptor subtype in cerebral blood vessels pharmacologically by correlation analysis and molecularly by Northern blot hybridization of cerebrovascular RNA extracts. Pharmacological analysis… CONTINUE READING

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