Expression of mRNA encoding insulin-like growth factors I and II by uterine tissues and placenta during pregnancy in the rat.

@article{CorreiadaSilva1999ExpressionOM,
  title={Expression of mRNA encoding insulin-like growth factors I and II by uterine tissues and placenta during pregnancy in the rat.},
  author={Georgina Correia-da-Silva and Stephen Charles Bell and James Howard Pringle and Nat{\'e}rcia A A Teixeira},
  journal={Molecular reproduction and development},
  year={1999},
  volume={53 3},
  pages={294-305}
}
The uterus and the placenta synthesize insulin-like growth factors (IGFs) and insulin-like binding proteins (IGFBPs). These growth factors are implicated in processes of proliferation and differentiation that occur in the uterus. To determine the patterns of expression of IGFs during rat pregnancy we used in situ hybridization with digoxigenin labeled probes on uterus from day 7 to day 16 of pregnancy. In early gestation days (7-8) both IGF mRNAs showed similar tissue distribution with relative… CONTINUE READING

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