Expression of lymphocyte activation gene 3 (LAG‐3) on B cells is induced by T cells

@article{Kisielow2005ExpressionOL,
  title={Expression of lymphocyte activation gene 3 (LAG‐3) on B cells is induced by T cells},
  author={Malgorzata Kisielow and Jan Kisielow and Giuseppina Capoferri-Sollami and Klaus Erik Karjalainen},
  journal={European Journal of Immunology},
  year={2005},
  volume={35}
}
Lymphocyte activation gene 3 (LAG‐3/CD223) is a CD4 homolog known to be selectively expressed in activated T and NK cells. It is thought to have a negative regulatory function in T cells. With the help of new monoclonal antibodies against mouse LAG‐3, we show that LAG‐3 surface expression is not limited to activated T and NK cells but is also found on activated B cells. Induction of B cell surface expression is T cell dependent and mediated by a soluble factor. The majority of LAG‐3 on B cell… Expand
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References

SHOWING 1-10 OF 35 REFERENCES
The CD4‐related molecule, LAG‐3 (CD223), regulates the expansion of activated T cells
TLDR
It is shown that Vβ7/8+LAG‐3–/– T cells expand poorly following staphylococcal enterotoxin B (SEB) stimulation in vitro, and a role for L AG‐3 in regulating the expansion of activated T cells is supported. Expand
Expression and release of LAG‐3‐encoded protein by human CD4+ T cells are associated with IFN‐γ production
The lymphocyte activation gene (LAG) ‐3 is a member of the immunoglobulin superfamily that is selectively transcribed in human activated T and NK cells. In this work, the possibility that LAG‐3Expand
Maturation and Activation of Dendritic Cells Induced by Lymphocyte Activation Gene-3 (CD223)1
TLDR
The effect of LAG-3Ig on the maturation and activation of human monocyte-derived dendritic cells (DC) is reported, which increases the capacity of DC to stimulate the proliferation and IFN-γ response by allogeneic T cells. Expand
Lymphocyte Activation Gene-3 (CD223) Regulates the Size of the Expanding T Cell Population Following Antigen Activation In Vivo1
TLDR
It is suggested that LAG-3 negatively regulates T cell expansion and controls the size of the memory T cell pool. Expand
Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-alpha and IL-12 production by monocytes and dendritic cells.
TLDR
Similar to CD40L, LAG-3 may be involved in the proinflammatory activity of cytokine-activated bystander T cells and most importantly it may directly activate DC. Expand
Biochemical Analysis of the Regulatory T Cell Protein Lymphocyte Activation Gene-3 (LAG-3; CD223)1
TLDR
This study shows that LAG-3 is cleaved within the D4 transmembrane domain connecting peptide into two fragments that remain membrane associated, which may contribute to the function of this key regulatory T cell protein. Expand
Lymphocyte activation gene‐3 induces tumor regression and antitumor immune responses
TLDR
It is suggested that LAG‐3 could be used as a vaccine adjuvant for its ability to trigger APC via MHC class II molecules. Expand
T cell major histocompatibility complex class II molecules down‐regulate CD4+ T cell clone responses following LAG‐3 binding
TLDR
Functional studies indicate that T cell MHC class II molecules down‐regulate T cell proliferation following LAG‐3 binding and suggest a role for L AG‐3 in the control of the CD4+ T cell response. Expand
LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination.
  • F. Triebel
  • Biology, Medicine
  • Trends in immunology
  • 2003
TLDR
Recent studies in mice have reconciled previous interpretations and clearly show that, as in human cells, LAG-3 negatively regulates T-cell function and homeostasis. Expand
Lymphocyte‐activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes
TLDR
The present analysis reveals a modulating effect of anti‐LAG‐3 mAb, mediated specifically on antigen‐dependent, MHC class II‐restricted responses of CD4+ T cell lines, and these results support the view that LAG‐ 3/MHCclass II interaction down‐regulates antigen‐ dependent stimulation of CD 4+ T lymphocytes. Expand
...
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3
4
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