Expression of liver-targeting peptide modified recombinant human endostatin and preliminary study of its biological activities

Abstract

Recombinant human endostatin (rEndostatin or endostar) has been shown to inhibit endothelial cells proliferation, migration, and angiogenesis and exhibits a broad spectrum of activities against solid tumors. However, rEndostatin is easily degradable and evenly distributed to all tissues. Selectively delivering rEndostatin to the lesion site might be more… (More)
DOI: 10.1007/s00253-014-5818-0

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