Expression of layer-specific markers in the adult neocortex of BCNU-Treated rat, a model of cortical dysplasia.

@article{Moroni2009ExpressionOL,
  title={Expression of layer-specific markers in the adult neocortex of BCNU-Treated rat, a model of cortical dysplasia.},
  author={Ramona Frida Moroni and Francesca Inverardi and Maria Cristina Regondi and Akiya Watakabe and Tetsuo Yamamori and Roberto Spreafico and Carolina Frassoni},
  journal={Neuroscience},
  year={2009},
  volume={159 2},
  pages={682-91}
}
The experimental model of cortical dysplasia (CD) obtained by administering carmustine (1-3-bis-chloroethyl-nitrosurea [BCNU]) in pregnant rat uterus mimics the histopathological abnormalities observed in human CD patients: altered cortical layering, and presence of heterotopia and dysmorphic/heterotopic neurons. To investigate further the cortical layering disruption and the neuronal composition of heterotopia in BCNU-exposed cortex, we analyzed the expression pattern of the transcription… CONTINUE READING
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Comparative analysis of layer-specific genes in mammalian neocortex

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