Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid.

@article{Archin2009ExpressionOL,
  title={Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid.},
  author={Nancie M. Archin and Amy Espeseth and Daniel N. Parker and M Atif Raza Cheema and Daria Hazuda and David M Margolis},
  journal={AIDS research and human retroviruses},
  year={2009},
  volume={25 2},
  pages={207-12}
}
Histone deacetylases (HDACs) act on histones within the nucleosome-bound promoter of human immunodeficiency virus type 1 (HIV-1) to maintain proviral latency. HDAC inhibition leads to promoter expression and the escape of HIV from latency. We evaluated the ability of the potent inhibitor recently licensed for use in oncology, suberoylanilide hydroxamic acid (SAHA; Vorinostat), selective for Class I HDACs, to induce HIV promoter expression in cell lines and virus production from the resting CD4… CONTINUE READING
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