Expression of kinin receptor mRNA in the HPA axis of type 1 and type 2 diabetic rats.

  title={Expression of kinin receptor mRNA in the HPA axis of type 1 and type 2 diabetic rats.},
  author={Fatimunnisa Qadri and E Stark and Walter H{\"a}user and Olaf J{\"o}hren and Andreas Dendorfer and Peter Dominiak},
  journal={International immunopharmacology},
  volume={4 4},
Expression and distribution of kinin B1 receptor in the rat brain and alterations induced by diabetes in the model of streptozotocin
Results highlight an early but transient and reversible up‐regulation of B1 receptors in specific brain regions of STZ‐diabetic rats, which may offer the advantage of reducing putative central side effects with B1 receptor antagonists if used for the treatment of diabetic complications in the periphery.
Acute hypothalamo-pituitary-adrenal axis response to LPS-induced endotoxemia: expression pattern of kinin type B1 and B2 receptors
The data demonstrate that a single injection of LPS induced a differential expression pattern of kinin B1R and B2R in the HPA axis, which indicates that they may play a crucial role in the maintenance of body homeostasis during endotoxemia.
Autoradiographic distribution and alterations of kinin B2 receptors in the brain and spinal cord of streptozotocin‐diabetic rats
Data suggest a very discrete and temporal increase of B2 receptor density (without affinity changes) in the spinal cord and hindbrain of STZ‐diabetic rats.
Kinin B1 receptors as a therapeutic target for inflammation
This review intends to evaluate the therapeutic potential of substances interacting with the BKB1R and summarized the published literature on animal studies with antagonists and knockout mice for this receptor to discuss possible reasons for this failure of translation of preclinical findings on B KB1R antagonists into the clinic.
Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation.
EGF-promoted Ser-727 phosphorylation by ERK-1/2 is not only sufficient to fully activate hypothalamic STAT-3, but, in terms of targeted genes and required cofactors, entails distinct modes ofSTAT-3 actions compared with IFN-γ-induced Tyr-705 phosphorylated.


Kinin B1 and B2 receptor mRNA expression in the hypothalamus of spontaneously hypertensive rats.
It is concluded that B1 and B2 receptor mRNA are differentially expressed in the hypothalamus of SHR and may play different roles in the pathogenesis of hypertension: upregulation of B2 receptors mRNA from early age may participate in the course of hypertension, whereas an up regulation of B1 receptor mRNA in the established phase of hypertension may reflect an epiphenomenon in essential hypertension.
Molecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: effects of insulin treatment.
Insulin apparently restored HPA activity at and below the pituitary but, surprisingly, not above it in STZ-diabetes.
Induction of B1 receptors in streptozotocin diabetic rats: possible involvement in the control of hyperglycemia-induced glomerular Erk 1 and 2 phosphorylation.
We investigated the effects of a 3-week treatment with various combinations of angiotensin-converting enzyme inhibitor (ACEI) and B1 and B2 bradykinin receptor (B1R and B2R) antagonists (B1A and B2A)
Kinin receptors in the diabetic mouse.
The results suggest that B1 and B2 receptors are overexpressed in the stomach fundus but not in the urinary bladder of diabetic mice, according to the apparent affinities of all agonists.
Autoradiographic detection of kinin receptors in the human medulla of control, hypertensive, and diabetic donors.
A putative role for kinins in the regulation of autonomic, nociceptive, and motor functions at the level of the human medulla is found and evidence is provided that B2 receptors are upregulated in medullary cardiovascular centers of subjects afflicted of cardiovascular diseases.
Pharmacological characterization of the cardiovascular responses elicited by kinin B1 and B2 receptor agonists in the spinal cord of streptozotocin‐diabetic rats
The data suggest that the activation of kinin B1 receptor in the spinal cord of STZ‐diabetic rats leads to cardiovascular changes through a prostaglandin mediated mechanism.
Role of brain kallikrein-kinin system in regulation of adrenocorticotropin release.
The brain kallikrein-kinin system may play a role in the regulation of ACTH secretion in stimulated conditions.
Abnormal regulation of the hypothalamo-pituitary-adrenal axis in the genetically obese fa/fa rat.
It is proposed that the increased HPA axis activity in obese rats and its resultant hypercorticism play a role in the establishment and maintenance of their syndrome.