Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayer.

@article{Basuroy2003ExpressionOK,
  title={Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayer.},
  author={Shyamali Basuroy and Parimal Sheth and Dhan Kuppuswamy and Sundar Balasubramanian and Ramesh Ray and RadhaKrishna Rao},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 14},
  pages={11916-24}
}
The activity of Src kinases appears to play a role in both assembly and disassembly of tight junction. However, the role of a specific isoform of Src kinase in regulation of tight junction is not known. In the present study the role of c-Src in regulation of epithelial tight junction was investigated in Caco-2 cell monolayers. Oxidative stress (xanthine oxidase + xanthine) induced an activation and membrane translocation of c-Src. The oxidative stress-induced decrease in transepithelial… CONTINUE READING