Expression of intrinsic factor in rat and murine gastric mucosal cell lineages is modified by inflammation.

@article{Shao2000ExpressionOI,
  title={Expression of intrinsic factor in rat and murine gastric mucosal cell lineages is modified by inflammation.},
  author={J S Shao and Ryan Balfour Sartor and Elizabeth J. Dial and Lenard M. Lichtenberger and Wolfgang Schepp and David H. Alpers},
  journal={The American journal of pathology},
  year={2000},
  volume={157 4},
  pages={1197-205}
}
Intrinsic factor is produced primarily by chief cells in rat and mouse, but 4 to 11% of isolated rat parietal cells also contain intrinsic factor. To test whether local conditions could alter the distribution of intrinsic factor expression, two rodent models of chronic lymphocytic gastric inflammation were examined. Immunocytochemistry was performed using antiserum against human intrinsic factor and H/K ATPase (a parietal cell marker), counting the percent of intrinsic factor-positive parietal… CONTINUE READING