Expression of interstitial collagenase is restricted to skeletal tissue during mouse embryogenesis.

@article{Mattot1995ExpressionOI,
  title={Expression of interstitial collagenase is restricted to skeletal tissue during mouse embryogenesis.},
  author={Virginie Mattot and M B Raes and Patrick Henriet and Yves Eeckhout and Dominique St{\'e}helin and Bernard Vandenbunder and Xavier Desbiens},
  journal={Journal of cell science},
  year={1995},
  volume={108 ( Pt 2)},
  pages={529-35}
}
Collagenases are thought to be involved in physiological and pathological processes that require extracellular matrix remodeling. Using the in situ hybridization technique, we describe the expression of interstitial collagenase gene during mouse embryogenesis between E6.5 and E17. We demonstrate that interstitial collagenase expression is exclusively detected in one event, namely the onset of bone formation. Transcripts accumulate in hypertrophied chondrocytes, found in the mature cartilaginous… CONTINUE READING

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