Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis.

@article{Juengel2004ExpressionOI,
  title={Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis.},
  author={Astrid Juengel and J{\"o}rg H. W. Distler and Mariola Kurowska-Stolarska and Christian Alexander Seemayer and Reinhart Seibl and Adrian Forster and Beat Michel and Renate Erika Gay and Frank Emmrich and S. Kirsten Gay and Oliver Distler},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 5},
  pages={1468-76}
}
OBJECTIVE To determine the role and expression of the cytokine/receptor pair interleukin-21 (IL-21)/IL-21 receptor (IL-21R) in rheumatoid arthritis (RA). METHODS The expression of IL-21R and IL-21 was analyzed by TaqMan real-time polymerase chain reaction (PCR) and in situ hybridization of synovial biopsy samples from patients with RA and osteoarthritis (OA). Double labeling by immunohistochemistry after in situ hybridization was performed with anti-CD68 antibodies. The expression of IL-21R… CONTINUE READING
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