Expression of interferon gamma by a highly virulent strain of Newcastle disease virus decreases its pathogenicity in chickens.

@article{Susta2013ExpressionOI,
  title={Expression of interferon gamma by a highly virulent strain of Newcastle disease virus decreases its pathogenicity in chickens.},
  author={Leonardo Susta and Ingrid Cornax and Diego G Diel and Stivalis Cardenas Garcia and Patti J. Miller and Xiufan Liu and Shunling Hu and Corrie C. Brown and Claudio L Afonso},
  journal={Microbial pathogenesis},
  year={2013},
  volume={61-62},
  pages={
          73-83
        }
}
The role of interferon gamma (IFN-γ) expression during Newcastle disease virus (NDV) infection in chickens is unknown. Infection of chickens with highly virulent NDV results in rapid death, which is preceded by increased expression of IFN-γ in target tissues. IFN-γ is a cytokine that has pleiotropic biological effects including intrinsic antiviral activity and immunomodulatory effects that may increase morbidity and mortality during infections. To better understand how IFN-γ contributes to NDV… CONTINUE READING
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