Expression of intercellular adhesion molecule-1 in atherosclerotic plaques.

  title={Expression of intercellular adhesion molecule-1 in atherosclerotic plaques.},
  author={Robin N Poston and Dorian O. Haskard and John Coucher and Nick P Gall and R R Johnson-Tidey},
  journal={The American journal of pathology},
  volume={140 3},
Immunohistochemistry of human atherosclerotic arteries demonstrates expression of the intercellular adhesion molecule-1 (ICAM-1) on endothelial cells, macrophages, and smooth muscle cells of the plaques. Normal arterial endothelial cells and intimal smooth muscle outside plaques give weaker or negative reactions; these differ from the strong endothelial expression in small vessels. Quantitative color-image analysis of the endothelial layer shows increased expression of ICAM-1 in all subtypes of… CONTINUE READING


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