Expression of insulin receptor substrate 1 in primary breast cancer and lymph node metastases

@article{Koda2005ExpressionOI,
  title={Expression of insulin receptor substrate 1 in primary breast cancer and lymph node metastases},
  author={M. Koda and M. Sułkowska and L. Kanczuga-Koda and S. Sulkowski},
  journal={Journal of Clinical Pathology},
  year={2005},
  volume={58},
  pages={645 - 649}
}
Background: Insulin receptor substrate 1 (IRS-1) transmits signals from the insulin-like growth factor I receptor (IGF-IR) and insulin receptor (IR) and has been associated with the pathogenesis of cancer. IRS-1 downregulation has been suggested to play a role in breast cancer progression, but no simultaneous assessments of IRS-1 expression in primary breast cancer and metastases have been performed. Aims: To assess IRS-1 expression in primary and metastatic breast cancer. Methods: IRS-1… Expand
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