Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon.

@article{Olesen2006ExpressionOI,
  title={Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon.},
  author={Jens Lykkegaard Olesen and Katja Maria Heinemeier and Fadia H Haddad and Henning Langberg and Allan Flyvbjerg and Michael Kjaer and Kenneth M. Baldwin},
  journal={Journal of applied physiology},
  year={2006},
  volume={101 1},
  pages={183-8}
}
Insulin-like growth factor I (IGF-I) is known to exert an anabolic effect on tendon fibroblast production of collagen. IGF-I's regulation is complex and involves six different IGF binding proteins (IGFBPs). Of these, IGFBP-4 and -5 could potentially influence the effect of IGF-I in the tendon because they both are produced in fibroblast; however, the response of IGFBP-4 and -5 to mechanical loading and their role in IGF-I regulation in tendinous tissue are unknown. A splice variant of IGF-I… CONTINUE READING
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