Expression of insulin growth factor‐1 splice variants and structural genes in rabbit skeletal muscle induced by stretch and stimulation

@article{Mckoy1999ExpressionOI,
  title={Expression of insulin growth factor‐1 splice variants and structural genes in rabbit skeletal muscle induced by stretch and stimulation},
  author={G. Mckoy and W. Ashley and J. Mander and S. Y. Yang and N. Williams and B. Russell and G. Goldspink},
  journal={The Journal of Physiology},
  year={1999},
  volume={516}
}
1 Skeletal muscle is a major source of circulating insulin growth factor‐1 (IGF‐1), particularly during exercise. It expresses two main isoforms. One of the muscle IGF‐1 isoforms (muscle L.IGF‐1) is similar to the main liver IGF‐1 and presumably has an endocrine action. The other muscle isoform as a result of alternative splicing has a different 3′ exon sequence and is apparently designed for an autocrine/paracrine action (mechano‐growth factor, MGF). Using RNase protection assays with a probe… Expand
The role of the insulin-like growth factor 1 (IGF-1) in skeletal muscle physiology.
TLDR
The concept that the competing processes of cellular proliferation and differentiation and the increased protein synthesis required for muscle repair or hypertrophic adaptation are regulated by a differential expression and by distinct roles of IGF-1 isoforms is discussed in the present review. Expand
The differential Role of Insulin-like Growth Factor-1 Isoforms in Skeletal muscle
TLDR
The present work constitutes the first evidence for different functions of IGF-1 isoforms in vitro and in vivo, and provides an overview of their variable effects in skeletal muscle and a strong basis for future research into their specific functions. Expand
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TLDR
The data in young subjects indicate that the MGF and IGF‐IEa isoforms are differentially regulated in human skeletal muscle, and an attenuated MGF response to high resistance exercise in the older subjects is indicative of age‐related desensitivity to mechanical loading. Expand
The splicing of the IGF-I gene to yield different muscle growth factors.
TLDR
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TLDR
The data indicate the importance of seeking to understand the physiological signals that determine the ratios of splice variants of some growth factor/tissue factor genes in the early stages of development of skeletal muscle. Expand
Expression of insulin-like growth factor 1 isoforms in the rabbit oculomotor system.
  • Cheng-Yuan Feng, C. V. von Bartheld
  • Biology, Medicine
  • Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2011
TLDR
Examination of relatively abundant amounts of both IGF-1 splicing isoforms in EOMs, and at a significantly higher level than in limb skeletal muscle, underscores the potential relevance of these myogenic growth factors in E OM plasticity and force regulation. Expand
IGF-I EXPRESSION IN SKELETAL MUSCLE
Skeletal muscle-derived insulin-like growth factor I (IGF-I) expression plays a significant role in mediating muscle hypertrophy induced by mechanical loading (4, 5). The present study investigatedExpand
Mechanical regulation of IGF‐I and IGF‐binding protein gene transcription in bladder smooth muscle cells
TLDR
The results suggest that the downstream effects of mechanical strain on IGF‐I and IGFBP transcript levels are mediated, to greater or lesser extent, either through an angiotensin II tranducing pathway or via a feedback loop involving the autocrine secretion of IGF‐ I itself. Expand
Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon.
TLDR
Loading of tendon tissue results in an upregulation of IGF-I, IGFBP-4, and procollagen and is associated with an increase in tendon mass, suggesting that the IGF- I system could be involved in collagen synthesis in tendon in response to mechanical loading. Expand
Expression and Splicing of the Insulin‐Like Growth Factor Gene in Rodent Muscle is Associated with Muscle Satellite (stem) Cell Activation following Local Tissue Damage
TLDR
To gain insight into the cellular mechanisms involved in local tissue repair, the time courses of expression of two IGF‐I splice variants produced in muscle were determined together with marker genes for satellite cell activation following local muscle damage and it was found that the autocrine splice variant mechano growth factor (MGF) was rapidly expressed and then declined within a few days following both types of damage. Expand
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