Expression of inflammatory chemokines combined with local tumor destruction enhances tumor regression and long-term immunity.

@article{Crittenden2003ExpressionOI,
  title={Expression of inflammatory chemokines combined with local tumor destruction enhances tumor regression and long-term immunity.},
  author={Marka R. Crittenden and Michael Gough and Kevin Harrington and Ken Olivier and Jill Thompson and Richard G. Vile},
  journal={Cancer research},
  year={2003},
  volume={63 17},
  pages={5505-12}
}
Expression of chemokines within tumors can be used to recruit immature dendritic cells (DCs) for the initiation of antitumor T-cell responses. Here, we describe the chemokine receptor expression on murine bone marrow-derived immature DCs. On the basis of these receptor studies, we chose to express the chemokines CCL3 (Mip-1alpha) or CCL20 (Mip-3alpha) in tumors. We show that expression of these chemokines in the colorectal tumor model CMT93 significantly decreases tumorigenesis. This decrease… CONTINUE READING
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