Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures.

@article{Dawson1994ExpressionOI,
  title={Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures.},
  author={Valina L Dawson and H P Brahmbhatt and Jessica A. Mong and Ted M Dawson},
  journal={Neuropharmacology},
  year={1994},
  volume={33 11},
  pages={1425-30}
}
Nitric oxide (NO) is a potent biological messenger molecule in the central nervous system (CNS). There are several potential sources of NO production in the CNS, including neurons and endothelial cells which express NO synthase (NOS) constitutively. Astrocytes and microglia can be induced by cytokines to express a NOS isoform similar to macrophage NOS (mNOS). Primary mixed glial cultures exposed to lipopolysaccharide (LPS) or a combination of LPS and gamma-interferon (INF-gamma) produce nitrite… CONTINUE READING

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