Expression of inducible nitric oxide synthase during cisplatin-based chemotherapy for gastric cancer.


BACKGROUND Nitric oxide (NO) has been reported to protect cells from apoptosis during chemotherapy. In this study, the protective role of inducible nitric oxide synthase (iNOS) against cisplatin (CDDP)-induced apoptosis was evaluated in a cell line and in patients with gastric cancer. MATERIALS AND METHODS MKN-45 cells were incubated with CDDP and the… (More)


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