Expression of inducible membrane-anchored insulin receptor kinase enhances deoxyglucose uptake.

@article{Lebwohl1991ExpressionOI,
  title={Expression of inducible membrane-anchored insulin receptor kinase enhances deoxyglucose uptake.},
  author={David Lebwohl and Ignacio N{\'u}{\~n}ez and Michelle P Y Chan and Ora M. Rosen},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 1},
  pages={
          386-90
        }
}
An Aspartate/Insulin Receptor Chimera Mitogenically Activates Fibroblasts*
TLDR
It is demonstrated that a chimeric receptor containing procaryotic transmembrane sequences is expressed by a eucaryotic cell in intracellular membranes and functionally couples to cellular signaling pathways.
The Carboxyl Terminal Extension of the DrosophilaInsulin Receptor Homologue Binds IRS-1 and Influences Cell Survival*
TLDR
Overexpression of INR β-Myc and βΔ kinases conferred an equivalent increase in cell proliferation in both 293 and Madin-Darby canine kidney cells, indicating that this growth response is independent of the carboxyl-terminal extension.
Reconstitution of Phosphoinositide 3-Kinase-dependent Insulin Signaling in a Cell-free System*
TLDR
Evidence is presented indicating that the critical spatial compartmentalization of signaling molecules necessary for efficient signal transduction is likely to be preserved in the cell-free system and data are provided demonstrating that full Akt activation in this system is dependent on plasma membrane-associated IRS-1, cannot be mediated by robust cytosol-specific tyrosine phosphorylation of IRS- 1, and occurs in the complete absence of detectable IRS-2 phosphorylated in the cytosols and plasma membrane.
Constitutive Proteolysis of the ErbB-4 Receptor Tyrosine Kinase by a Unique, Sequential Mechanism
TLDR
A unique pathway for the processing of growth factor receptors is described, which involves the sequential function of an exofacial metalloprotease and the cytoplasmic proteasome.
Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons
TLDR
This work suggests that insulin plays a significant role in mediating neuronal glucose metabolism, potentially through an upregulation in the expression of GLUT3, and provides further evidence for a potential therapeutic mechanism underlying the beneficial impact of intranasal insulin in the clinic.
Expression of a Constitutively Active Human Insulin Receptor in Hippocampal Neurons Does Not Alter VGCC Currents
TLDR
Results suggest that there is a significant difference between constitutively active insulin receptors and the actions of insulin on an intact receptor, highlighting potential alternate mechanisms of neuronal insulin resistance and mode of activation.
Effects of tyrosine-->phenylalanine mutations on auto- and trans-phosphorylation reactions catalyzed by the insulin receptor beta-subunit cytoplasmic domain.
TLDR
Findings imply that autoactivation can occur without phosphorylation having occurred at any single site, and autophosphorylation need not follow an ordered, sequential pathway beginning, for example, at tyrosine 1,146 as proposed for the intact insulin receptor.
Genistein Is a Natural Inhibitor of Hexose and Dehydroascorbic Acid Transport through the Glucose Transporter, GLUT1 (*)
TLDR
The data indicate that genistein inhibits the transport of dehydroascorbic acid and hexoses by directly interacting with the hexose transporter GLUT1 and interfering with its transport activity, rather than as a consequence of its known ability to inhibit protein-tyrosine kinases.
Effect of cell attachment and growth on the synthesis and fate of dolichol-linked oligosaccharides in Chinese hamster ovary cells.
TLDR
Using metabolic labelling it is demonstrated that suspended cells have a low incorporation rate into lipid intermediates and into glycoproteins, and variations in the nature and in the quantity of soluble oligosaccharide material as a function of the cell density reflects regulatory points in the synthesis of N-glycosyl proteins.
...
...