Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival.

@article{Brody2009ExpressionOI,
  title={Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival.},
  author={Jonathan R. Brody and Christina L. Costantino and Adam C Berger and Takami Sato and Michael Phillip Lisanti and Charles J Yeo and Robert V B Emmons and Agnieszka K. Witkiewicz},
  journal={Cell cycle},
  year={2009},
  volume={8 12},
  pages={1930-4}
}
The mechanism by which malignant melanoma (MM) cells survive in lymph nodes is poorly understood. One possible mechanism by which MM cells can escape immune surveillance is through upregulation of immunomodulatory enzymes such as indoleamine 2,3-dioxygenase (IDO). In this study, 25 cases of MM lymph node metastases from patients with long and short survival were evaluated for expression of IDO and the number of Forkhead box p3 (FOXP3)-expressing regulatory T cells. Moderate to strong… CONTINUE READING

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