Expression of immunoglobulin delta chain causes allelic exclusion in transgenic mice

@article{Iglesias1987ExpressionOI,
  title={Expression of immunoglobulin delta chain causes allelic exclusion in transgenic mice},
  author={Antonio Iglesias and Marinus C. Lamers and G. W. K{\"o}hler},
  journal={Nature},
  year={1987},
  volume={330},
  pages={482-484}
}
Rearrangement of the separated V, D and J segments of immunoglobulin heavy and light chain genes is an ordered and regulated process essential for the production and diversification of antibodies in mammals1. Only one allele of the heavy and light chain gene locus is found functionally rearranged in normal B cells. The second allele is either non… CONTINUE READING