Expression of immunogenic epitopes of hepatitis B surface antigen with hybrid flagellin proteins by a vaccine strain of Salmonella.

@article{Wu1989ExpressionOI,
  title={Expression of immunogenic epitopes of hepatitis B surface antigen with hybrid flagellin proteins by a vaccine strain of Salmonella.},
  author={Jane Y. Wu and Stephanie Newton and Ali Judd and Bruce L Stocker and William S. Robinson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 12},
  pages={4726-30}
}
A nonvirulent Salmonella dublin flagellin-negative, aromatic-dependent live vaccine strain has been used to express hepatitis B virus surface antigen epitopes in an immunogenic form. The envelope proteins of the virion are encoded by the S gene, which contains the pre-S1, pre-S2, and S coding regions. Synthetic oligonucleotides corresponding to amino acid residues S-(122-137) and pre-S2-(120-145) were inserted in-frame into the hypervariable region of a cloned Salmonella flagellin gene, and the… CONTINUE READING

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