Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.

@article{Turner2002ExpressionOH,
  title={Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.},
  author={Kevin J. Turner and John W M Moore and Adam Thomas Jones and Claire Fraser Taylor and Darren Cuthbert-Heavens and Cheng Han and R. Leek and Kevin C. Gatter and Patrick Henry Maxwell and Peter J Ratcliffe and David Cranston and Adrian L. Harris},
  journal={Cancer research},
  year={2002},
  volume={62 10},
  pages={2957-61}
}
The von Hippel-Lindau tumor suppressor protein acts as the substrate recognition component of a ubiquitin E3 ligase that targets hypoxia-inducible factor (HIF)-alpha subunits for proteolysis. Stabilization of HIF-alpha subunits has been described in VHL-defective cell lines, leading to HIF activation and up-regulation of hypoxia-inducible mRNAs. Mutations of the von Hippel-Lindau tumor suppressor protein are found in most clear cell renal cell carcinomas (CC-RCCs) but not other renal tumors… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 96 extracted citations

Targeted therapies for renal cell carcinoma

Targeted Oncology • 2006
View 4 Excerpts
Highly Influenced

Correlation between BOLD-MRI and HIF expression level in renal carcinoma.

International journal of clinical and experimental pathology • 2015
View 1 Excerpt

Similar Papers

Loading similar papers…